Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch

نویسندگان

چکیده

BackgroundApproved food and drug administration (FDA) medications to treat Psychostimulant Use Disorder (PUD) are needed. Both acute chronic neurological deficits related the neurophysiological effects of these powerfully addictive drugs can cause stroke alterations in mood cognition.ObjectiveThis article presents a brief review psychiatric neurobiological sequelae methamphetamine use disorder, some known neurogenetic associations impacted by psychostimulants, explores treatment modalities outcomes.HypothesisThe authors propose that gentle D2 receptor stimulation accomplished via induce dopamine release, causing alteration D2-directed mRNA thus enhanced function receptors human. This proliferation receptors, turn, will attenuation craving behavior, especially genetically compromised high-risk populations.DiscussionA better understanding involvement molecular opioid, mesolimbic dopamine, psychostimulant connections “wanting” supports this hypothesis. While both scientific and, clinical professionals search for an FDA approved PUD induction homeostasis, activation brain reward circuitry, offers underlying neurotransmitter functional deficits, potential prophylaxis, support recovery efforts.ConclusionDopamine regulation may help people dig out their hypodopaminergia ditch.

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ژورنال

عنوان ژورنال: Journal of the Neurological Sciences

سال: 2021

ISSN: ['0022-510X', '1878-5883']

DOI: https://doi.org/10.1016/j.jns.2020.117252